After the destruction of the Super Mutant Army, a Brotherhood of Steel expedition travels east across the ruins of post-nuclear America to expand the order's influence and recover advanced technology. When disaster leaves the survivors stranded in the Midwest, they establish a new chapter and begin recruiting local wastelanders to strengthen their ranks. As a newly inducted squad leader, you command a team of soldiers through dangerous missions against raiders, mutants, robots, and other deadly threats while forging alliances with isolated communities. What begins as a struggle for survival gradually uncovers a far greater danger lurking beneath the surface: a powerful army of intelligent machines known as the Calculator. Facing overwhelming odds, your tactical decisions, leadership, and battlefield strategy will determine the fate of the Midwest Brotherhood and whether humanity can withstand a new technological menace in the unforgiving wasteland.