Set several years after the events of Devil May Cry 4, Devil May Cry 5 follows the demon hunter Nero as he faces a mysterious new threat when a giant demonic tree called the Qliphoth emerges and begins draining human blood to gain immense power. Joined by the legendary demon hunter Dante and a mysterious newcomer named V, Nero embarks on a dangerous mission to stop the invasion and uncover the truth behind the powerful demon king Urizen. As the story unfolds, long-hidden secrets, family ties, and painful pasts are revealed, connecting all three heroes in unexpected ways. Through intense battles and emotional moments, they must work together to save humanity and confront a destiny that will forever change the future of the demon-hunting world.